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Publications

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Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to Heart Failure with Preserved Ejection Fraction (HFpEF)

bioRxiv - October 25, 2024

In a new preprint manuscript, Dr. Gibb was the First-Author and a corresponding author on a study utilizing omics approaches, in vivo phenotyping, and mitochondrial ultrastructure and functional analyses to identify key contributors of HFpEF disease progression. Stay tuned for updates on its journal submission status. Congrats Dr. Gibb!

Glutamine Uptake and Catabolism is Required for Myofibroblast Formation and Persistance

JMCC - August 18, 2022

In this manuscript, Dr. Gibb uses isotope tracing studies to identify glutamine as the primary source for alpha-ketoglutarate biosynthesis, which contributes to enhanced alpha-ketoglutarate dependent lysine demethylase activity and chromatin remodeling, necessary for fibroblast to myofibroblast differentiation.

Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure

Circulation - May 24, 2022

Dr. Gibb does it again! Publishing in Circulation, Dr. Gibb shows it is possible to target myofibroblast glutamine utilization to improve cardiac remodeling during heart failure. This work also showed the impact of targeting this metabolic pathway in fibroblasts isolated from the human failing heart!

Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model

JACC: BTS - August 23, 2021

In JACC Basic Translational Science, Dr. Gibb publishes his first original research article in the Elrod Lab. Here, Dr. Gibb used systems biology to define progressive changes in metabolism and transcription in a feline model of HFpEF. Results from these studies revealed gross remodeling of mitochondrial function and metabolism, likely underlying disease development.

Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation

Circulation Research - July 16, 2020

Dr. Gibb first authors another review in Circulation Research, this time highlighting and discussing how mitochondrial processes and metabolism coordinate to mediate fibroblast differentiation to promote tissue fibrosis.

Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretations.

Scientific Reports - September 23, 2019

In a co-first authorship manuscript, Dr. Gibb shows how integration of flux methodologies and use of pharmacological controls increase confidence in SIRM data and provide new biological insights.

Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis

JCI - December 3, 2018

Dr. Gibb's first publication in the Elrod Lab is a commentary on a new role for ALDH2 in cardiovascular disease development.

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Circulation Research - June 22, 2018

Dr. Gibb and Dr. Hill put together an excellent review published in Circulation Research on how metabolism responds and contribute to cardiac remodeling during physiological and pathological stressors.

Exercise-induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth

Circulation - August 31, 2017

In Dr. Gibb's manuscript in Circulation, he was the first to identify that exercise-induced decreases in glycolytic activity stimulate physiological cardiac remodeling, activating physiological growth transcriptional programs. This seminal work provide the first evidence of exercise-mediated metabolic remodeling in the adaptive responses to chronic exercise training.

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The work was highlighted in an editorial by none other than

Dr. Heinrich Taegtmeyer!!!

Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes.

Biochemical Journal - August 7, 2017

In this study, Dr. Gibb utilize radiometric, isotope tracing, and extracellular flux analyses in cardiomyocytes to under how changes in glycolytic activity mediated catabolic and anabolic metabolism. 

FVB/NJ mice are a useful model for examining cardiometabolic adaptations to treadmill exercise.

Frontiers Phys - December 21, 2016

Dr. Gibb established a treadmill exercise training protocol for FVB/NJ mice which demonstrate the strain is more adept at this exercise regimen.

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