Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to Heart Failure with Preserved Ejection Fraction (HFpEF)
bioRxiv - October 25, 2024
In a new preprint manuscript, Dr. Gibb was the First-Author and a corresponding author on a study utilizing omics approaches, in vivo phenotyping, and mitochondrial ultrastructure and functional analyses to identify key contributors of HFpEF disease progression. Stay tuned for updates on its journal submission status. Congrats Dr. Gibb!
Glutamine Uptake and Catabolism is Required for Myofibroblast Formation and Persistance
JMCC - August 18, 2022
In this manuscript, Dr. Gibb uses isotope tracing studies to identify glutamine as the primary source for alpha-ketoglutarate biosynthesis, which contributes to enhanced alpha-ketoglutarate dependent lysine demethylase activity and chromatin remodeling, necessary for fibroblast to myofibroblast differentiation.
Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure
Circulation - May 24, 2022
Dr. Gibb does it again! Publishing in Circulation, Dr. Gibb shows it is possible to target myofibroblast glutamine utilization to improve cardiac remodeling during heart failure. This work also showed the impact of targeting this metabolic pathway in fibroblasts isolated from the human failing heart!
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
JACC: BTS - August 23, 2021
In JACC Basic Translational Science, Dr. Gibb publishes his first original research article in the Elrod Lab. Here, Dr. Gibb used systems biology to define progressive changes in metabolism and transcription in a feline model of HFpEF. Results from these studies revealed gross remodeling of mitochondrial function and metabolism, likely underlying disease development.
Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation
Circulation Research - July 16, 2020
Dr. Gibb first authors another review in Circulation Research, this time highlighting and discussing how mitochondrial processes and metabolism coordinate to mediate fibroblast differentiation to promote tissue fibrosis.
Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretations.
Scientific Reports - September 23, 2019
In a co-first authorship manuscript, Dr. Gibb shows how integration of flux methodologies and use of pharmacological controls increase confidence in SIRM data and provide new biological insights.
Metabolic Coordination of Physiological and Pathological Cardiac Remodeling
Circulation Research - June 22, 2018
Dr. Gibb and Dr. Hill put together an excellent review published in Circulation Research on how metabolism responds and contribute to cardiac remodeling during physiological and pathological stressors.
Exercise-induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth
Circulation - August 31, 2017
In Dr. Gibb's manuscript in Circulation, he was the first to identify that exercise-induced decreases in glycolytic activity stimulate physiological cardiac remodeling, activating physiological growth transcriptional programs. This seminal work provide the first evidence of exercise-mediated metabolic remodeling in the adaptive responses to chronic exercise training.
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The work was highlighted in an editorial by none other than
Dr. Heinrich Taegtmeyer!!!
Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes.
Biochemical Journal - August 7, 2017
In this study, Dr. Gibb utilize radiometric, isotope tracing, and extracellular flux analyses in cardiomyocytes to under how changes in glycolytic activity mediated catabolic and anabolic metabolism.